D'Orland KEG Ltd.

Assay Standards

2010-02-04T09:54:00.003+01:00

Key Organics has launched the Bionet Assay Standard Collection; designed and sourced specifically to satisfy Bionet customer demand for small, screening sized quantities of specific assay standards for comparison testing and screening. This is in keeping with Key Organics' drive to consistently listen to customers' changing needs, providing reliable solutions to their problems.

The Bionet Assay Standard Collection eliminates unnecessary wastage of cumbersome bulk quantities of active ingredients and saves customers' money by providing bespoke mg quantities according to individual requirements rather than a 'standard pack size'. The Bionet Assay Standard Collection contains a diverse selection of assay standards, including APIs, Peptides, Natural Products, Hormones and Metabolites. All are available in screening size quantities for research purposes. These compounds can be purchased as part of a Bionet screening/fragment compound order for one stop shop needs or they can be purchased individually.

pdf/Assay%20Standards%200909.pdf

Chiral Resolving Agents

2009-10-14T09:36:00.001+01:00

We have the following Chiral Resolving Agents available:

(-)-Di-p-toluoyl-(L)-tartaric acid monohydrate / anhdyrous [32634-66-5]
(+)-Di-p-toluoyl-(D)-tartaric acid monohydrate / anhydrous [32634-68-7]
(-)-Dibenzoyl-(L)-tartaric acid monohydrate / anhydrous [2743-38-6]
(+)-Dibenzoyl-(D)-tartaric acid monohydrate / anhydrous [17026-42-5]
(+).Diacetyl-(L)-tartaric anhydride [6283-74-5]
(-)-Di-o-toluoyl-(L)-tartaric acid monohydrate / anhydrous
M-Toyl-(+)-gluatmic acid [4816-80-2]
S-(+)-alpha methoxyphenylacetic acid [26164-26-1]

Please contact us for further information!

Catalyst Kits from Johnson Matthey

2009-10-09T09:05:00.001+01:00

Johnson Matthey offers a multitude of Catalyst Kits which are an excellent tool for your various research projects. They contain a collection of novel catalysts, ligands and metal scavenging products.

For more information please contact us!

pdf/Catalyst%20kits.pdf

Grignard Reagents

2009-10-07T15:22:00.002+01:00

Pentagon's purpose built Grignard plant at Workington offers advanced capability in the manufacture of reagents and their downstream derivatives. In addition to a wide range of own products in standard solvents and concentrations we offer custom manufacture of downstream products utilising more concentrated solutions than could be commercially shipped.

The Grignard plant in Workington has the following technology available:

* 4 – 4.5m3 GL and SS vessels
* Fully DCS controlled Temperature -15°C to 150°C
* Distillation unit with 26 theoretical plates
* Hastelloy filter dryer
* Bulk and drums

A full list of the Grignard reagents which are available:

xls/Grs.xls

Palladium Catalysts for Alpha-arylation

2009-10-06T21:23:00.001+01:00

Johnson Matthey has recently identified:
(DtBPF) PdCl2 Pd-118
(DtBPF) PdBr2 Pd-128
as exceptional candidates for alpha-arylation of
various ketones with a variety of aryl
chlorides and aryl bromides.

These catalysts:
-are commercially available from JM
-give excellent yield and selectivity
-are air stable
-perform with mild reaction conditions
-demonstrate minimal Pd leaching

Learn more at:

A Highly Practical and General Route for α-Arylations of ketones Using Bis-phosphinoferrocene-Based Palladium Catalysts
Gabriela A. Grasa* and Thomas J. Colacot
Org. Process Res. Dev., 2008, 12 (3), pp 522-529

α-Arylation of Ketones Using Highly Active, Air-Stable (dtBPF)PdX2 (X - Cl, Br) Catalysts
Gabriela A. Grasa and Thomas J. Colacot*
Org. Lett., 2007 9 (26), pp 5489-5492

Organozinc Halides

2009-10-06T21:20:00.000+01:00

BASF is sponsoring an on-line seminar on organozinc reagents that
can help pharmaceutical and chemical research chemists bring new
products to market. The Web-based discussion is scheduled for
October 27, and will be available at two different time slots to
accommodate participants from North America, Europe and Asia.

Organozinc compounds are selective reagents and represent a powerful
tool for carbon-carbon bond forming reactions. Over the last
decades, organozinc reagents have been widely used in the total
synthesis of natural products, in medicinal chemistry as well as in
asymmetric synthesis and catalysis. This presentation will cover
recent developments of the Negishi cross coupling technology and
applications of this novel transformation on scale.

The seminar "Organozinc Halides in Organic Synthesis" will be
presented by Dr. Andreas Leitner, Senior Research Scientist,
Inorganics for BASF in North America at two live sessions:

* The first session begins at 5 a.m. Eastern Daylight Time (EDT)
or 10 a.m. Central European Time (CET), 2:30 p.m. in India,
and 6 p.m. in Japan and Korea
* The second session begins at 2 p.m. EDT, or 11 a.m. Pacific Time

Registration for both sessions is available at
_www.v-workshops.com/pby/basf_

Quinuclidine Intermediates

2009-10-06T20:58:00.003+01:00

We have recently added a range of Quinuclidine Intermediates:

3-Quinuclidinone Hcl [1193-65-3]
2-Methylene-3-Quinuclidinone Hcl [207556-03-4]
3-Quinuclidinol (base or Hcl)[1619-34-7]
3-Aminoquinuclidine diHcl [6530-09-2]
3-Chloromethylquinuclidine
3-Hydroxyquinuclidine Cyanhdyride [6238-30-8]
3-Acetoxyquinuclidine[827-61-2]

Grignard Reactions, Grignard Solvents and Grignard Reagents from Pentagon Chemical Specialities, Penn Speciality Chemicals and Ferro Fine Chemicals

2007-09-25T16:13:00.000+01:00

D'Orland supplies a wide range of Reagents and Solvents for Grignard Reactions from it's principals, Pentagon Chemical Specialities, Penn Speciality Chemicals and Ferro Fine Chemicals. Products available include Methyl Tetrahydrofuran (2-Methyl THF, MeTHF) and Butyl Diglyme (Diethylene Glycol Dibutyl Ether) as well as other Glymes (Glycol Diethers) which both make for safer Grignards as well as full range of Grignard reagents including Allyl Magnesium Chloride, Butyl Magnesium Chloride, Ethyl Magnesium Bromide, Ethyl Magnesium Chloride, Methyl Magnesium Bromide, Methyl Magnesium Chloride, Phenyl Magnesium Chloride, Phenyl Magnesium Bromide, Tert-Butyl Magnesium Chloride to name a few. These reagents are all available in various solvents, including Toluene, THF and Diethyl Ether, whilst we can also make the next step of the reation under contract. Please do no hesistate to contact us for further information.

Homogenous and Heterogenous Catalysts, Enzymes and Metathesis from Johnson Matthey

2007-07-31T10:33:00.000+01:00

D'Orland represents Johnson Matthey Catalysts and Chiral Technologies in Hungary, Poland, The Czech and Slovak Republics as well as Croatia and Slovenia for their excellent range of Heterogenous, Homogenous, Sponge Nickel and Metal scavenging agents, the latter being marketed under the Smopex name.

If a catalyst could be of interest for your rection, then please do not hesitate to contact us and we will endevour to recommend the ideal catalyst for the synthesis in question.

There is also a wealth of information available to help with the correct choice of catalyst, be it a homogenous or heterogenous one. A good place to start is the catalyst technical handbook We can of course also post the very useful reaction guide to interested parties, but the Hetergenous Screening Kit certainly should be part of any laboratory where catalysis is being looked at and every kit kit comes with an excellent reaction chart. That a number of factors can affect the performance of a catalyst and that a 5 % or 10 % Palladium on Carbon is not just that, is show on the following sheets concerning O-Debenzylation and N-Benzylation.

For homogenous catalytic reactions the Coupling Table should enable the choice of an ideal catalyst and again there is a Chiral Coupling Kit available. Details of other homogenous catalytic reactions using rhodium, iridium and ruthernium are can be downloaded as well as information on Chiral Technologies for carbon - oxygen and carbon nitrogen coupling reactions.

There is of course also more information on the fourth generation of coupling catalysts, where Pd-118 ( Dichloro [1,1'-bis (di-tert butyl-phosphino) ferrocene] Palladium (II) ) could be of particular interest due to the fact that it is both air and moisture stable enabling some reactions to be carried out in a mixture of water and ethanol and avoiding the need for the catalyst to be stored in a glove box.

Johnson Matthey have also recently added a range of catalytic enzymes to their range, which show high enantiouselectivity particularly for ketone reductions.

A range of Metathesis Catalysts has also been introduced recently and these do currently fall outside the scope of the patents on the Grubbs type catalysts.

The good old tried and trusted Sponge Metal Catalysts which are made by the Raney Process, are of course also available!

Lastly, Smopex® should not be forgotten and a short presentation about Smopex illustrates why it should always be considered when a precious metal catalyst is used to recover as much of the palladium, platinum, ruthenium or rhodium as possible.

BASF Inorganics: Boron Reducing Agents for Assymetric Synthesis and Suzuki Coupling. Metal Alcoholates for Deprotonation.

2007-04-16T11:43:00.000+01:00

D'Orland can offer a full range of Alkali Metal Deprotonating agents (such as Potassium-Tert-Butoxide and Sodium-Tert-Amylate), Boron Reducing Agents and Suzuki Cross-Coupling Reagents for the Croatian, Slovenian, Hungarian, Czech and Slovak markets.

Furthermore Coreys Catalyst (Methyl Oxazaborolidine) is now available commercially and further information on the Corey Catalyst is on D'Orland's products page.

An interesting presentation on Metal Alcoholates and Boron Reagents for Organic Synthesis is available here whilst a short presentation on Suzuki Cross Coupling Reagents is available here.

Please do not hesitate to contact us for more information on these or any other BASF Inorganics Products.

High Purity Organic Bases

2007-03-02T15:07:00.000+01:00

Since the 1950's Tetramethyl Ammonium Hydroxide has been used in the electrochemicals industries as a metal free base. More recently though, thanks to the work of Prof. Charles Little and others, strong organic bases such as TMAH and others have gain wide-spread acceptance in other fields of organic chemistry.

The applications of TMAH and other related products such as Tetraethyl Ammonium Hydroxide and Benzyltrimethyl Ammonium Hydroxide for use in pharmaceutical organic synthesis is also being examined very carefully.

Sachem Inc. our partner for organic strong bases, have been producing these bases for over 50 years and thanks to their special processes can produce these materials with impurity profiles sometimes being measured at an incredible ppt level (yes, that's parts per trillion!).

For more information please see this fascinating White Paper by Prof. Charles Little.

Methyl Tetrahydrofuran (MeTHF)

2007-02-26T17:58:00.000+01:00

Methyl Tetrahydrofuran has often been over-looked as purely an over-expensive grignard solvent, with no real benefits over regular THF - except for it's higher boiling point. But this is to overlook the very clean phase splits and recycleability of the product - not to mention the fact that it is produced from corn husks - a renewal source. All this goes to make MeTHF a very ecologically sound choice. Read more in the downloadable pdf from Penn:

MeTHF for Greener Processes

Alternatively find out more from an independent source